PRIMONUS® Tablets

PRIMONUS® Tablets
Generic Name:
Norethisterone
Therapeutic Group:
Gynecology / Endocrinology
Drug Category:
Progestogen (Synthetic Progesterone)
Content / Composition:
Each tablet contains:
* Norethisterone …… 5 mg
Indications:
Indicated for the management of menstrual and hormonal disorders, including:
* Dysfunctional uterine bleeding (DUB)
* Menorrhagia (heavy menstrual bleeding)
* Irregular menstrual cycles
* Secondary amenorrhea
* Endometriosis
* Premenstrual syndrome (PMS)
* Delay of menstruation (under medical supervision)
Dosage:
As directed by the physician.
Typical regimens:
* Menstrual disorders: 5 mg, 2–3 times daily for 5–10 days
* Delay of menstruation: Start 3 days before expected period, continue as prescribed
* Endometriosis: Continuous dosing as per clinical guidance
Contraindications:
* Known or suspected pregnancy
* Active thromboembolic disorders
* Severe liver disease
* Hormone-dependent malignancies (e.g., breast cancer)
* Undiagnosed vaginal bleeding
* Hypersensitivity to norethisterone
Administration:
For oral use.
Take with water, with or without food.
Maintain regular dosing schedule for optimal effect.
Interaction:
Use caution with:
* Enzyme-inducing drugs (rifampicin, phenytoin, carbamazepine)
* Anticoagulants
* Antidiabetic drugs
* Herbal products (e.g., St. John’s Wort)
Compatibility:
Can be used with other hormonal therapies under medical supervision.
Monitoring required when combined with estrogen-containing therapies.
Stability / Storage:
Store below 25°C.
Protect from light and moisture.
Keep out of reach of children.
Precautions:
* Monitor for risk of thrombosis
* Use with caution in cardiovascular disease
* Monitor liver function in long-term use
* Caution in diabetic patients
* Not recommended during pregnancy
* Evaluate abnormal bleeding before treatment
Side Effects:
Common:
* Nausea
* Headache
* Breast tenderness
* Mood changes
Others:
* Weight gain
* Fluid retention
* Irregular bleeding or spotting
Rare but serious:
* Thromboembolic events
* Hepatic dysfunction
* Visual disturbances
Website Note (Professional):
This medicine should be used only under medical supervision.
Individual risk-benefit assessment is essential before initiating therapy.