SITA-H Tablets
SITA-H Tablets
Generic Name:
Sitagliptin 50 mg + Metformin Hydrochloride 1000 mg
Therapeutic Group:
Antidiabetic Combination
Drug Category:
DPP-4 Inhibitor + Biguanide
Content / Composition:
Each film-coated tablet contains:
Sitagliptin ……………………………… 50 mg
Metformin Hydrochloride ………… 1000 mg
Excipients ……………………………… q.s.
Indications:
SITA-H is indicated for:
Type 2 Diabetes Mellitus
Patients inadequately controlled with metformin alone or other oral agents
Improvement of glycemic control (fasting and postprandial glucose)
Combination therapy to enhance insulin secretion and reduce hepatic glucose production
Dosage:
One tablet twice daily with meals (or as directed by physician)
Dose should be individualized based on glycemic response
Gradual titration recommended to reduce gastrointestinal side effects
Contraindications:
Type 1 Diabetes Mellitus
Diabetic ketoacidosis
Severe renal impairment (eGFR <30 mL/min)
Severe hepatic disease
Hypersensitivity to sitagliptin or metformin
Conditions associated with lactic acidosis
Pregnancy and lactation
Administration:
Administer orally with meals
Swallow whole with water
Do not skip meals to reduce risk of hypoglycemia and GI side effects
Drug Interactions:
Increased hypoglycemia risk with insulin or sulfonylureas
Metformin interaction with iodinated contrast agents (risk of lactic acidosis)
Reduced efficacy with corticosteroids and diuretics
Alcohol increases risk of lactic acidosis
Compatibility:
Suitable for combination with insulin or other oral antidiabetic agents
Compatible with comprehensive diabetes management protocols
Stability / Storage:
Store below 25°C
Protect from moisture, heat, and light
Keep out of reach of children
Precautions:
Risk of lactic acidosis (due to metformin)
Monitor renal function regularly
Risk of pancreatitis (rare with DPP-4 inhibitors)
Monitor blood glucose levels
Use cautiously in elderly patients
Suspend before surgery or contrast imaging
Side Effects:
Common:
Gastrointestinal disturbances (nausea, diarrhea)
Headache
Hypoglycemia (when combined with other agents)
Uncommon:
Fatigue
Dizziness
Serious (Rare):
Lactic acidosis
Pancreatitis
Hypersensitivity reactions
Important Note:
SITA-H is a fixed-dose combination for effective glycemic control in Type 2 Diabetes Mellitus. It should be used under strict medical supervision. This information is intended for healthcare professionals and educational purposes only.
FEVER-H® Tablets (Ibuprofen 400 mg)
FEVER-H® Tablets (Ibuprofen 400 mg)
Generic Name:
Ibuprofen
Therapeutic Group:
Analgesic, Antipyretic & Anti-inflammatory
Drug Category:
Non-Steroidal Anti-Inflammatory Drug (NSAID)
Content / Composition:
Each tablet contains:
* Ibuprofen BP …… 400 mg
* Excipients …… q.s.
Indications:
* Fever (Pyrexia)
* Mild to moderate pain
* Headache
* Toothache
* Musculoskeletal pain
* Back pain
* Dysmenorrhea (menstrual pain)
* Inflammatory conditions (e.g. arthritis)
* Cold & flu symptoms
Dosage:
As directed by the physician
Adults:
* 200–400 mg every 6–8 hours
* Maximum: 1200–2400 mg/day (depending on clinical condition)
Children (>6 months):
* 5–10 mg/kg every 6–8 hours
* Maximum: 40 mg/kg/day
⚠️ Use lowest effective dose for shortest duration
Contraindications:
* Hypersensitivity to ibuprofen or NSAIDs
* History of NSAID-induced asthma
* Active peptic ulcer or GI bleeding
* Severe heart failure
* Severe renal or hepatic impairment
* Third trimester of pregnancy
Administration:
* Oral use
* Take with food or after meals to reduce gastric irritation
* Swallow with sufficient water
Interaction:
* Anticoagulants (Warfarin) → increased bleeding risk
* Aspirin → reduced cardioprotective effect
* ACE inhibitors & diuretics → reduced renal function
* Corticosteroids → increased GI risk
* Lithium → increased lithium levels
Compatibility:
* Compatible with paracetamol in combination therapy (under supervision)
* Avoid concurrent use with other NSAIDs
Stability / Storage:
* Store below 25°C
* Protect from light and moisture
* Keep out of reach of children
Precautions:
* Use cautiously in elderly patients
* Risk of GI ulceration and bleeding
* Monitor renal function in long-term use
* Caution in cardiovascular disease
* Avoid prolonged self-medication
Side Effects:
Common:
* Gastric irritation
* Nausea
* Dyspepsia
Less Common:
* Headache
* Dizziness
* Fluid retention
Serious (rare):
* GI bleeding or ulcer
* Renal impairment
* Hypersensitivity reactions
* Cardiovascular events (with long-term/high dose use)
Professional Summary:
FEVER-H® (Ibuprofen 400 mg) is a globally recognized NSAID providing:
✔️ Rapid fever reduction
✔️ Effective pain relief
✔️ Anti-inflammatory action
Widely used as a first-line therapy for fever, pain, and inflammatory conditions with strong clinical reliability.







