CLARICIN-H Dry Suspension 250 mg/5 mL

CLARICIN-H Dry Suspension 250 mg/5 mL
Generic Name:
Clarithromycin Oral Suspension 250 mg/5 mL
Therapeutic Group:
Antibacterial
Drug Category:
Macrolide Antibiotic
Content / Composition:
After reconstitution, each 5 mL contains:
Clarithromycin ………………… 250 mg
Excipients …………………… q.s.
(Flavored Pediatric Suspension – Strawberry)
Indications:
CLARICIN-H is indicated for the treatment of susceptible bacterial infections in children, including:
Upper respiratory tract infections (pharyngitis, tonsillitis, sinusitis)
Lower respiratory tract infections (bronchitis, pneumonia)
Acute otitis media
Skin and soft tissue infections
Atypical infections (Mycoplasma, Chlamydia)
Dosage (Pediatric):
General Dose:
7.5 mg/kg twice daily for 5–10 days
Maximum dose:
Up to 500 mg twice daily (as per physician guidance)
Important:
Dose should be adjusted according to body weight and severity of infection
Contraindications:
Hypersensitivity to clarithromycin or macrolides
Severe hepatic impairment with renal dysfunction
History of QT prolongation
Concomitant use with drugs like cisapride, pimozide, ergot derivatives
Administration:
For oral use
Shake well before use
Use calibrated measuring device
May be taken with or without food
Complete full course of therapy
Reconstitution Instructions:
Add recommended amount of clean water
Shake vigorously to form uniform suspension
Drug Interactions:
CYP3A4 inhibitors/substrates (e.g., statins, benzodiazepines)
Warfarin → increased bleeding risk
Theophylline → increased plasma levels
Carbamazepine → toxicity risk
QT-prolonging drugs → arrhythmia risk
Compatibility:
Effective against Gram-positive, Gram-negative, and atypical pathogens
Ideal for respiratory infections
Pediatric-friendly formulation with improved taste
Twice-daily dosing improves compliance
Stability / Storage:
Store dry powder below 25°C
After reconstitution: use within 7–14 days
Keep tightly closed
Protect from light and moisture
Precautions:
Use cautiously in hepatic impairment
Monitor cardiac patients (QT prolongation risk)
Risk of antibiotic resistance with misuse
Observe for allergic reactions
Side Effects:
Common:
Nausea
Diarrhea
Abdominal pain
Uncommon:
Headache
Taste disturbance
Rash
Serious (Rare):
Hepatotoxicity
QT prolongation / arrhythmias
Severe hypersensitivity reactions
Clinical Advantage:
CLARICIN-H offers:
Strong respiratory coverage
Effective against atypical pathogens
Pediatric-friendly taste (Strawberry flavor)
Reliable twice-daily dosing regimen
High tissue penetration for faster recovery
Packaging:
Dry Suspension Bottle (After Reconstitution: 50 mL)
Measuring cup / oral syringe included