ZUROXIM 625 mg Tablets (Cefuroxime 500 mg + Clavulanic Acid 125 mg)

ZUROXIM 625 mg Tablets
(Cefuroxime 500 mg + Clavulanic Acid 125 mg)
Generic Name:
Cefuroxime Axetil + Clavulanic Acid
Therapeutic Group:
Antibacterial
Drug Category:
Second-Generation Cephalosporin + Beta-Lactamase Inhibitor
Content / Composition:
Each film-coated tablet contains:
Cefuroxime Axetil …………… 500 mg
Clavulanic Acid ……………… 125 mg
Excipients …………………… q.s.
Indications:
ZUROXIM 625 mg is indicated for moderate to severe bacterial infections including:
Upper respiratory tract infections (sinusitis, tonsillitis, pharyngitis)
Lower respiratory infections (acute bronchitis, pneumonia)
Urinary tract infections (complicated & uncomplicated)
Skin and soft tissue infections
Ear infections (otitis media)
Dental infections
Bone and joint infections
Infections caused by beta-lactamase producing organisms
Dosage:
Adults:
1 tablet twice daily (every 12 hours)
Severe infections:
May require higher dose or physician adjustment
Duration:
Typically 5–10 days depending on infection severity
Contraindications:
Hypersensitivity to cephalosporins, penicillins, or beta-lactam antibiotics
History of severe allergic reactions (anaphylaxis)
Severe hepatic dysfunction associated with clavulanate
Administration:
Oral administration
Take with food to improve absorption and reduce GI upset
Swallow whole with water
Do not skip doses — complete full course
Drug Interactions:
Probenecid → increases cefuroxime levels
Anticoagulants (e.g., warfarin) → increased bleeding risk
Oral contraceptives → reduced efficacy
Nephrotoxic drugs → caution required
Compatibility / Clinical Benefits:
Broad-spectrum antibacterial coverage
Effective against resistant beta-lactamase producing bacteria
Dual-action mechanism enhances efficacy
Suitable for severe and mixed infections
Reliable oral alternative to injectable antibiotics
Stability / Storage:
Store below 25°C
Protect from moisture and direct light
Keep in original packaging
Precautions:
Use cautiously in renal impairment (dose adjustment required)
Monitor liver function in prolonged therapy
Risk of antibiotic-associated colitis
Avoid unnecessary prolonged use to prevent resistance
Side Effects:
Common:
Diarrhea
Nausea
Abdominal discomfort
Uncommon:
Headache
Skin rash
Elevated liver enzymes
Serious (Rare):
Hypersensitivity reactions
Stevens-Johnson Syndrome
Hepatic dysfunction
Clinical Advantages:
ZUROXIM 625 mg provides:
High-strength broad-spectrum coverage
Enhanced activity against resistant pathogens
Rapid infection control
Ideal for moderate to severe infections
Packaging:
6 × 2 Tablets (Blister Pack)
Film-Coated Tablets