SUBCLAV Pediatric Suspension

SUBCLAV Pediatric Suspension
(Co-Amoxiclav 156 mg / 25 mg per 5 mL)
(Amoxicillin + Clavulanic Acid)
Generic Name:
Amoxicillin + Clavulanic Acid
Therapeutic Group:
Antibacterial
Drug Category:
Beta-lactam Antibiotic Combination
(Aminopenicillin + Beta-lactamase Inhibitor)
Content / Composition:
After reconstitution, each 5 mL contains:
Amoxicillin (as trihydrate) ………… 156 mg
Clavulanic Acid (as potassium clavulanate) ………… 25 mg
Excipients ………………………………… q.s.
Indications:
Indicated in pediatric patients for treatment of infections caused by beta-lactamase producing organisms:
Upper respiratory tract infections (tonsillitis, sinusitis)
Lower respiratory tract infections (bronchitis, pneumonia)
Acute otitis media
Urinary tract infections
Skin & soft tissue infections
Dental infections
Dosage:
Children (≥ 3 months):
Based on amoxicillin component:
20–40 mg/kg/day divided every 8–12 hours
Mild to Moderate infections:
20–25 mg/kg/day
Severe infections:
Up to 40 mg/kg/day
⚠️ Dose must be adjusted based on body weight and severity
Contraindications:
Hypersensitivity to penicillins or beta-lactams
History of co-amoxiclav-related hepatic dysfunction or jaundice
Administration:
Oral use only
Reconstitute with boiled & cooled water up to mark
Shake well before each dose
Administer at the beginning of meals
Complete full treatment course
Drug Interactions:
Allopurinol → ↑ risk of rash
Warfarin / anticoagulants → ↑ bleeding risk
Methotrexate → ↑ toxicity
Probenecid → ↑ amoxicillin levels
Compatibility / Clinical Benefits:
Effective against beta-lactamase producing bacteria
Suitable for pediatric use (low clavulanate dose → better tolerability)
Broad-spectrum antibacterial coverage
Improved compliance due to pleasant flavor
Stability / Storage:
Store dry powder below 25°C
After reconstitution:
Keep refrigerated (2–8°C preferred)
Use within 7 days
Do not freeze
Keep bottle tightly closed
Precautions:
Use cautiously in hepatic impairment
Monitor liver function in prolonged therapy
Risk of antibiotic-associated diarrhea
Use with caution in renal impairment
Avoid unnecessary prolonged use
Side Effects:
Common:
Diarrhea
Nausea
Vomiting
Uncommon:
Rash
Oral thrush
Serious (Rare):
Hepatic dysfunction
Hypersensitivity reactions
Stevens-Johnson Syndrome
Pseudomembranous colitis
Clinical Advantages:
SUBCLAV 156/25 mg is specially designed for:
Young pediatric patients
Better GI tolerability (low clavulanate ratio)
Safe and effective early-line antibiotic therapy
Packaging:
60 mL bottle (after reconstitution)
Measuring cup + oral syringe included