DAIBET-M2 Tablets

DAIBET-M2 Tablets
Generic Name:
Glimepiride 2 mg + Metformin Hydrochloride 500 mg
Therapeutic Group:
Antidiabetic Combination
Drug Category:
Sulfonylurea (Insulin Secretagogue) + Biguanide
Content / Composition:
Each film-coated tablet contains:
Glimepiride …………………………… 2 mg
Metformin Hydrochloride ………… 500 mg
Excipients ……………………………… q.s.
Indications:
DAIBET-M2 is indicated for:
Type 2 Diabetes Mellitus
Patients inadequately controlled with monotherapy
Improvement of glycemic control (fasting and postprandial glucose)
Combination therapy to enhance insulin secretion and reduce hepatic glucose production
Dosage:
One tablet once or twice daily with meals
Dose should be individualized based on blood glucose levels
Maximum dose determined by physician
Gradual dose titration recommended
Contraindications:
Type 1 Diabetes Mellitus
Diabetic ketoacidosis
Severe renal impairment (eGFR <30 mL/min)
Severe hepatic disease
Hypersensitivity to sulfonylureas or metformin
Conditions predisposing to lactic acidosis
Pregnancy and lactation
Administration:
Administer orally with meals to reduce gastrointestinal side effects
Swallow whole with water
Do not skip meals (risk of hypoglycemia)
Drug Interactions:
Increased hypoglycemic effect with insulin, NSAIDs, and certain antibiotics
Metformin interaction with contrast media (risk of lactic acidosis)
Reduced effect with corticosteroids, diuretics, and oral contraceptives
Alcohol increases risk of hypoglycemia and lactic acidosis
Compatibility:
Suitable for combination with insulin or other oral antidiabetic agents
Compatible with comprehensive diabetes management plans
Stability / Storage:
Store below 25°C
Protect from heat, moisture, and light
Keep out of reach of children
Precautions:
Risk of hypoglycemia (due to glimepiride)
Risk of lactic acidosis (due to metformin)
Monitor renal function regularly
Use cautiously in elderly patients
Suspend before major surgery or contrast imaging procedures
Lifestyle modification (diet & exercise) is essential
Side Effects:
Common:
Hypoglycemia
Gastrointestinal upset (nausea, diarrhea)
Headache
Dizziness
Uncommon:
Weight changes
Vitamin B12 deficiency (long-term use)
Serious (Rare):
Lactic acidosis
Severe hypoglycemia
Allergic reactions
Important Note:
DAIBET-M2 is a fixed-dose combination used for glycemic control in Type 2 Diabetes Mellitus. It should be used under strict medical supervision. This information is intended for healthcare professionals and educational purposes only.