SITA-H Tablets

SITA-H Tablets
Generic Name:
Sitagliptin 50 mg + Metformin Hydrochloride 500 mg
Therapeutic Group:
Antidiabetic Combination
Drug Category:
DPP-4 Inhibitor + Biguanide
Content / Composition:
Each film-coated tablet contains:
Sitagliptin ……………………………… 50 mg
Metformin Hydrochloride ………… 500 mg
Excipients ……………………………… q.s.
Indications:
SITA-H is indicated for:
Type 2 Diabetes Mellitus
Patients inadequately controlled on metformin or other oral antidiabetic agents
Improvement of glycemic control (fasting and postprandial glucose)
Combination therapy to enhance insulin secretion and reduce hepatic glucose production
Dosage:
One tablet twice daily with meals (or as directed by physician)
Dose should be individualized based on glycemic response
Gradual titration recommended to minimize gastrointestinal side effects
Contraindications:
Type 1 Diabetes Mellitus
Diabetic ketoacidosis
Severe renal impairment (eGFR <30 mL/min)
Severe hepatic disease
Hypersensitivity to sitagliptin or metformin
Conditions predisposing to lactic acidosis
Pregnancy and lactation
Administration:
Administer orally with meals
Swallow whole with water
Do not skip meals
Drug Interactions:
Increased risk of hypoglycemia with insulin or sulfonylureas
Metformin interaction with iodinated contrast media
Reduced efficacy with corticosteroids and diuretics
Alcohol increases risk of lactic acidosis
Compatibility:
Suitable for combination with insulin or other oral antidiabetic agents
Compatible with comprehensive diabetes management protocols
Stability / Storage:
Store below 25°C
Protect from heat, moisture, and light
Keep out of reach of children
Precautions:
Risk of lactic acidosis (metformin component)
Monitor renal function regularly
Risk of pancreatitis (rare with sitagliptin)
Monitor blood glucose levels
Use cautiously in elderly patients
Suspend before surgery or contrast imaging procedures
Side Effects:
Common:
Gastrointestinal disturbances (nausea, diarrhea)
Headache
Hypoglycemia (when used with other agents)
Uncommon:
Dizziness
Fatigue
Serious (Rare):
Lactic acidosis
Pancreatitis
Hypersensitivity reactions
Important Note:
SITA-H is a fixed-dose combination for effective glycemic control in Type 2 Diabetes Mellitus. It should be used under strict medical supervision. This information is intended for healthcare professionals and educational purposes only.