SEPTRA-H DS® Tablets
Sulfamethoxazole 400 mg + Trimethoprim 80 mg Tablets BP
Generic Name:
Sulfamethoxazole + Trimethoprim (Co-trimoxazole)
Therapeutic Group:
Antibacterial (Sulfonamide + Folate Inhibitor Combination)
Drug Category:
Broad-Spectrum Antibiotic
Content / Composition:
Each tablet contains:
* Sulfamethoxazole …… 400 mg
* Trimethoprim …… 80 mg
* Excipients …… q.s.
Indications:
* Urinary tract infections (UTIs)
* Respiratory tract infections (bronchitis, pneumonia)
* Gastrointestinal infections (shigellosis, traveler’s diarrhea)
* Skin & soft tissue infections
* Ear infections (otitis media)
* Pneumocystis jirovecii pneumonia (PCP)
* Certain opportunistic infections
Dosage:
As directed by the physician
Adults:
* 1–2 tablets every 12 hours
Severe infections:
* Higher doses may be required under supervision
Children:
* Dose based on body weight
Renal impairment:
* Dose adjustment necessary
Contraindications:
* Hypersensitivity to sulfonamides or trimethoprim
* Severe liver disease
* Severe renal impairment (without monitoring)
* Megaloblastic anemia (folate deficiency)
* Infants < 2 months
Administration:
* Oral use
* Take with a full glass of water
* Preferably after meals
* Maintain adequate hydration
Interaction:
* Warfarin ↑ bleeding risk
* Phenytoin ↑ toxicity
* Methotrexate ↑ toxicity
* ACE inhibitors ↑ hyperkalemia risk
* Diuretics ↑ thrombocytopenia risk
Compatibility:
* Compatible with many antibiotic regimens
* Avoid unnecessary combination with folate antagonists
Stability / Storage:
* Store below 25°C
* Protect from light & moisture
* Keep in original packaging
Precautions:
* Risk of severe skin reactions (Stevens-Johnson Syndrome)
* Monitor renal and liver function
* Ensure adequate hydration
* Use cautiously in elderly patients
* Avoid prolonged sun exposure
Side Effects:
Common:
* Nausea
* Vomiting
* Loss of appetite
Less Common:
* Skin rash
* Headache
* Dizziness
Serious (Rare):
* Stevens-Johnson Syndrome (SJS)
* Toxic Epidermal Necrolysis (TEN)
* Blood disorders (anemia, leukopenia)
* Hyperkalemia
Professional Summary:
SEPTRA-H DS® is a well-established combination antibiotic offering:
✔️ Dual mechanism (bacteriostatic synergy)
✔️ Broad-spectrum antibacterial activity
✔️ Effective against urinary, respiratory, and GI infections
Ideal for community-acquired infections and selected opportunistic infections.
